For twenty years, through their participation in a yearly symposium, the
American Academy of Orthopaedic Surgeons (AAOS) and the National Institute of
Arthritis and Musculoskeletal and Skin Diseases (NIAMS) at the National
Institutes of Health (NIH) have worked collaboratively to comprehensively
examine important scientific questions that face our profession. On April 25
through 28, 2007, leaders came together for the 2007 AAOS "Fracture
Repair: Challenges and Opportunities" research symposium. In this
twentieth symposium, prominent thought leaders—clinicians, scientists,
and clinician scientists—assembled to discuss questions, come to
consensus conclusions, and present a research agenda for the future.
The goal of the symposium was to define knowledge gaps in the area of
fracture-healing, to describe and evaluate the use of new therapies for
fracture repair, to examine successful models for translational research, and
to study ways to optimize functional and clinical outcomes in fracture
treatment now and in the future. Plenary lectures were delivered by the
participants, followed by open periods of time for discussion and exchange.
Breakout sessions were designed to further explore the issues that had been
brought forth in the lectures and to arrive at consensus decisions regarding
future areas of research to be explored.
The symposium findings were communicated to both the NIH and appropriate
AAOS committees in the hope that the results from the symposium would not only
help shape science policy but also lead to new funding mechanisms to explore
additional issues that arose during the conference.
A summary of the key findings of the symposium appears in The Orthopaedic
Forum of the February 2008 issue of The Journal. The Orthopaedic
Forum article also lists the presenters in the symposium. In addition, the
AAOS sponsored seven young investigator attendees who attended the symposium
and contributed substantively to its success. The following Young
Investigators were selected after a rigorous application process:
Céline Colnot, PhD, University of California, San FranciscoAnthony E. Johnson, MD, McDonald Army Health CenterPhillip Leucht, MD, Stanford UniversitySaam Morshed, MD, MPH, PhD, University of California, San FranciscoPatrick W. O'Donnell, MD, PhD, University of MinnesotaJohn J. Wixted, MD, University of Massachusetts Medical SchoolTerri A. Zachos, DVM, PhD, Michigan State University
Céline Colnot, PhD, University of California, San Francisco
Anthony E. Johnson, MD, McDonald Army Health Center
Phillip Leucht, MD, Stanford University
Saam Morshed, MD, MPH, PhD, University of California, San Francisco
Patrick W. O'Donnell, MD, PhD, University of Minnesota
John J. Wixted, MD, University of Massachusetts Medical School
Terri A. Zachos, DVM, PhD, Michigan State University
This supplement to The Journal of Bone and Joint Surgery provides
the proceedings of the symposium. Papers are presented in the order in which
they appeared in the symposium, with the following sections represented:
—Basic Science I: Tissue Response and Cellular Recruitment After
Skeletal Injury—Basic Science II: Cellular Signaling During Bone Formation and
Repair—Emerging Technologies in Fracture Repair—Critical Issues in Translational and Clinical Research for the Study
of New Technologies to Enhance Bone Repair
—Basic Science I: Tissue Response and Cellular Recruitment After
Skeletal Injury
—Basic Science II: Cellular Signaling During Bone Formation and
Repair
—Emerging Technologies in Fracture Repair
—Critical Issues in Translational and Clinical Research for the Study
of New Technologies to Enhance Bone Repair
These papers present a comprehensive overview of the challenges and
opportunities in the area of fracture repair. They were designed to be
concise, well referenced, and readable by clinicians and scientists alike.
The AAOS was fortunate to gain input from the United States Food and Drug
Administration (FDA), the National Institute on Aging (NIA), the National
Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), the
National Institute of Biomedical Imaging and Bioengineering (NIBIB), and the
Society of Military Orthopaedic Surgeons (SOMOS) through the attendance of
their representatives. Individuals in attendance included:
U.S. Food and Drug Administration (FDA) Barbara Buch, MD, Deputy
Director, Division of General, Restorative, and Neurological Devices (DGRND),
Center for Devices and Radiological Health (CDRH)/Office of Device Evaluation
(ODE)Theresa Kehoe, MD, Medical Officer, Center for Drug Evaluation and Research
(CDER)Ted Stevens, CDRH, ODE, DGRNDCelia M. Witten, MD, PhD, Director of the Office of Cellular, Tissue and
Gene Therapies at the Center for Biologics Evaluation and Research (CBER)National Institute on Aging (NIA) Evan Hadley, MD, Director,
Geriatrics and Clinical Gerontology ProgramNational Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS) James Panagis, MD, MPH, Director, Orthopaedic ProgramFei Wang, PhD, Director, Musculoskeletal Development, Tissue Engineering,
and Regenerative Medicine ProgramNational Institute of Biomedical Imaging and Bioengineering (NIBIB)
Roderic Pettigrew, PhD, MD, DirectorSociety of Military Orthopaedic Surgeons (SOMOS) Joseph C. Wenke,
PhD, SOMOS representative
U.S. Food and Drug Administration (FDA) Barbara Buch, MD, Deputy
Director, Division of General, Restorative, and Neurological Devices (DGRND),
Center for Devices and Radiological Health (CDRH)/Office of Device Evaluation
(ODE)
Theresa Kehoe, MD, Medical Officer, Center for Drug Evaluation and Research
(CDER)
Ted Stevens, CDRH, ODE, DGRND
Celia M. Witten, MD, PhD, Director of the Office of Cellular, Tissue and
Gene Therapies at the Center for Biologics Evaluation and Research (CBER)
National Institute on Aging (NIA) Evan Hadley, MD, Director,
Geriatrics and Clinical Gerontology Program
National Institute of Arthritis and Musculoskeletal and Skin Diseases
(NIAMS) James Panagis, MD, MPH, Director, Orthopaedic Program
Fei Wang, PhD, Director, Musculoskeletal Development, Tissue Engineering,
and Regenerative Medicine Program
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Roderic Pettigrew, PhD, MD, Director
Society of Military Orthopaedic Surgeons (SOMOS) Joseph C. Wenke,
PhD, SOMOS representative
The 2007 AAOS "Fracture Repair: Challenges and Opportunities"
Symposium received tremendous support and encouragement from the AAOS Research
Development Committee, which included Denis R. Clohisy, MD, and Christopher
Evans, PhD; the AAOS Council on Research, Quality Assessment, and Technology,
which included Joshua J. Jacobs, MD; and the AAOS Board of Directors, which
included James H. Beaty, MD, E. Anthony Rankin, MD, and Joseph Zuckerman, MD.
The success of the symposium was due in large part to the tremendous work of
the AAOS staff leadership, including Christy M.P. Gilmour, Erin L. Ransford,
Kristy Glass, Katherine Sale, and Brenda Frederick. All involved are thanked
for their help.
Finally, the 2007 AAOS Fracture Repair Symposium was fortunate to receive
financial support from a conference support grant (R13 AR054313) awarded by
the NIH/NIAMS. In addition, the AAOS received grant support from the
Orthopaedic Research Society and the Orthopaedic Research and Education
Foundation.
The AAOS acknowledges the following Industry Sponsors:
Smith and Nephew (Gold Sponsor)DePuy (Silver Sponsor)Kyphon (Silver Sponsor)Medtronic (Silver Sponsor)Stryker (Silver Sponsor)Synthes (Silver Sponsor)BioMimetic Therapeutics (Bronze Sponsor)
Smith and Nephew (Gold Sponsor)
DePuy (Silver Sponsor)
Kyphon (Silver Sponsor)
Medtronic (Silver Sponsor)
Stryker (Silver Sponsor)
Synthes (Silver Sponsor)
BioMimetic Therapeutics (Bronze Sponsor)
It is our hope that this supplement will not only inform those in our
profession but serve as a springboard for further thought and inquiry into
this important scientific area.