William S. Pietrzak, editor. Totowa, New Jersey: Humana Press; 2008. 649 pages. $229.00. ISBN: 978-1-58829-909-3.The practice of orthopaedic surgery has long depended on knowledge of biological processes and the application of biomechanical principles. At present, and certainly into the future, our ability to address diseases and disorders of the musculoskeletal system will be enhanced by our newfound ability to manipulate biology with the certainty, precision, and finesse previously reserved for our more mechanically based strategies. Collectively, these approaches are often referred to as tissue engineering. In large measure, these principles and practices reflect our recently acquired opportunity to introduce highly purified and well-characterized molecules, specific inducible cell populations, and physical forces that independently or indirectly influence other cell populations to cause repair or regeneration of the musculoskeletal system.