The Journal of Bone & Joint Surgery

The Journal of Bone & Joint Surgery, Volume 91, Issue Supplement 1

Section IV: Macromolecular Imaging of Cartilage | February 01, 2009

Section IV: Macromolecular Imaging of Cartilage

Xiaojuan Li, PhD¹; Sharmila Majumdar, PhD²

¹ Department of Radiology and Biomedical Imaging, University of California at San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107. E-mail address: xiaojuan.li@radiology.ucsf.edu
² Department of Radiology and Biomedical Imaging, University of California at San Francisco, QB3 Building, 2nd Floor, Suite 203, 1700 4th Street, San Francisco, CA 94158. E-mail address: sharmila.majumdar@radiology.ucsf.edu

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Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the National Institutes of Health. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity. No commercial entity paid or directed, or agreed to pay or direct, any benefits to any research fund, foundation, division, center, clinical practice, or other charitable or nonprofit organization with which the authors, or a member of their immediate families, are affiliated or associated.

The Journal of Bone and Joint Surgery, Inc.

J Bone Joint Surg Am, 2009 Feb 01;91(Supplement 1):43-43. doi: 10.2106/JBJS.H.01524

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Hyaline articular cartilage is composed of very few cells (chondrocytes), surrounded by a large extracellular matrix. The extracellular matrix is composed primarily of water and two macromolecules: the collagen fibers and the amorphous proteoglycan (or the associated glycosaminoglycans). Importantly, the macromolecular status of cartilage is inextricably responsible for the biomechanical properties and functional integrity of the tissue. Destruction of the collagen-proteoglycan matrix in cartilage has been shown to be the initial event during cartilage degradation in osteoarthritis. Over the past decade, considerable effort has been invested in developing imaging techniques that can detect the biochemical changes in cartilage matrix. This section provides an overview of several advanced magnetic resonance imaging techniques that can noninvasively detect macromolecular changes during cartilage degeneration or damage. Specifically, the delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC), sodium magnetic resonance imaging, and T2 and T1rho relaxation time mapping techniques are discussed in detail. In addition to technique development, the correlations with the changes in cartilage matrix during the course of cartilage degeneration are also discussed. These techniques have the potential to provide information beyond cartilage morphological changes with regard to early degeneration and biochemistry, which may improve our ability to understand and intervene in osteoarthritis and other diseases associated with cartilage degeneration. Image Not Available

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These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.

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Xiaojuan Li, Sharmila Majumdar; Section IV: Macromolecular Imaging of Cartilage. The Journal of Bone & Joint Surgery. 2009 Feb;91(Supplement_1):43-43.

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