Unregulated Growth   |    
Nerve Pathology in Unregulated Limb Growth
Mario I. Romero-Ortega, PhD1; Marybeth Ezaki, MD2
1 Department of Biomedical Engineering, University of Texas at Arlington, 701 South Nedderman Drive, Arlington, TX 76019
2 Department of Hand Surgery, Texas Scottish Rite Hospital for Children, 2222 Welborn Street, Dallas, TX 75219. E-mail address: Marybeth.ezaki@tsrh.org
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2009 Jul 01;91(Supplement 4):53-57. doi: 10.2106/JBJS.I.00166
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Limb overgrowth is a rare pathological condition that may affect either all tissues equally or some tissues selectively and may be associated with other systemic conditions, such as tumorigenesis. While much progress has been made in recent years regarding the molecular mechanisms involved in limb development and, in particular, the formation of new bone, the precise cause of limb overgrowth remains largely unknown. Recent emerging evidence in the converging fields of nerve-tumor biology and limb regeneration has provided evidence that the vascular and peripheral nervous systems might be critically involved in regulating limb size. In this paper, we review the evidence supporting the notion that peripheral nerve abnormalities might cause limb and/or digit overgrowth.
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    limb ; neurons ; neoplasms

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