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Locally Delivered Bisphosphonate for Enhancement of Bone Formation and Implant Fixation
J. Dennis Bobyn, PhD1; Kimberly McKenzie, BSc2; Dorota Karabasz, BSc2; Jan J. Krygier, CET2; Michael Tanzer, MD2
1 Montreal General Hospital, 1650 Cedar Avenue, Room LS1-409, Montreal, QC H3G 1A4, Canada. E-mail address for J.D. Bobyn: john.bobyn@mcgill.ca
2 Jo Miller Orthopaedic Research Laboratory, 1650 Cedar Avenue, Room LS1-409, Montreal, QC H3G 1A4, Canada
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Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the Canadian Institutes of Health Research. In addition, one or more of the authors or a member of his or her immediate family received, in any one year, payments or other benefits of less than $10,000 or a commitment or agreement to provide such benefits from commercial entities (Novartis Pharmaceuticals and Zimmer, Inc.).

The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2009 Nov 01;91(Supplement 6):23-31. doi: 10.2106/JBJS.I.00518
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Bone growth into porous materials has proven to be a very effective method for attaching prosthetic implants to the osseous skeleton1-3. However, there remains a need to develop modalities that can accelerate and/or increase biologic fixation. The more rapidly that bone forms and the greater the amount of bone that forms about and/or within an implant, the faster the implant becomes mechanically secured against the disruptive forces of load bearing and the sooner patients can safely return to their activities of daily living. In situations in which the condition of the bone stock or the healing process is compromised (e.g., when the patient is elderly or has osteoporosis) or the initial stability of the implant is more tenuous or crucial (e.g., during posttraumatic, revision, or minimally invasive procedures), the construct would clearly benefit from enhanced mechanical support.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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