Instructional Course Lecture   |    
Malignant Bone Tumors
C. Parker GibbsJr., MD; Kristy Weber, MD; Mark T. Scarborough, MD
J Bone Joint Surg Am, 2001 Nov 01;83(11):1728-1745
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Classic high-grade osteosarcoma is a highly malignant spindle-cell sarcoma of bone in which the malignant cells produce osteoid1. It is the most common primary malignant tumor of bone, excluding myeloma, and is the third most common malignant disease in adolescence after leukemia and lymphoma. However, it is still a rare tumor with only 1000 new cases per year in the United States. There appears to be no racial or ethnic influence associated with its incidence2. However, an increased prevalence has been noted in families affected with the Li-Fraumeni syndrome3 and in patients who have had retinoblastoma4 (a 40% prevalence in those with bilateral disease), have undergone radiation therapy5, or have Paget disease6.
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