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Clinical Trials in Orthopaedics Research. Part II. Prioritization for Randomized Controlled Clinical Trials
Jeffrey N. Katz, MD, MSc1; James G. Wright, MD, MPH2; Elena Losina, PhD1
1 Orthopedic and Arthritis Center for Outcome Research, Department of Orthopedic Surgery and Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, 75 Francis Street, OBC-4, Boston, MA 02115. E-mail address for J.N. Katz: jnkatz@partners.org
2 Department of Orthopaedic Surgery, The Hospital for Sick Children, 555 University Avenue, Toronto, ON M5G 1X8, Canada
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Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the R.B. Salter Chair in Surgical Research and from the National Institutes of Health grants AR02123 and AR057827, American Academy of Orthopaedic Surgeons, and Orthopaedic Research Society. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

This report is based on the Clinical Trials in Orthopaedics Research Symposium sponsored by the American Academy of Orthopaedic Surgeons and the Orthopaedic Research Society, Albuquerque, New Mexico, May 7, 8, and 9, 2009.

Copyright © 2011 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2011 Apr 06;93(7):e30 1-6. doi: 10.2106/JBJS.J.01039
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The American Academy of Orthopaedic Surgeons (AAOS) and Orthopaedic Research Society (ORS) Clinical Trials in Orthopaedics Research Symposium had three major themes including barriers to performing clinical trials, methodology of clinical trials, and prioritization of clinical questions in orthopaedics to address in randomized controlled trials. This paper addresses the latter theme. Clinical experts from the major orthopaedic specialties provided presentations on key issues in their respective fields that had been addressed with clinical trials and the clinical questions that were most appropriate and pressing for clinical trials.
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