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Aneurysmal Bone Cysts of Soft Tissue Represent True NeoplasmsA Report of Two Cases
Matthias F. Pietschmann, MD1; Andre M. Oliveira, MD2; Margaret M. Chou, PhD3; Stefan Ihrler, MD1; Manuel Niederhagen, MD1; Andrea Baur-Melnyk, MD1; Hans Roland Dürr, MD1
1 Orthopaedic Oncology, Department of Orthopaedics (M.F.P. and H.R.D.), Department of Pathology (S.I. and M.N.), and Department of Radiology (A.B.-M.), Ludwig-Maximilians University, Campus Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany. E-mail address for H.R. Dürr: hans_roland.duerr@med.uni-muenchen.de
2 Department of Anatomic and Clinical Pathology, Mayo Clinic, 200 First Street S.W., Rochester, MN 55905
3 Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, 3615 Civic Center Boulevard, ARC 816E, Philadelphia, PA 19105
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

Investigation performed at Ludwig-Maximilians University, Munich, Germany, and the Department of Anatomic and Clinical Pathology, Mayo Clinic, Rochester, Minnesota

Copyright © 2011 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2011 May 04;93(9):e45 1-8. doi: 10.2106/JBJS.J.00534
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Aneurysmal bone cyst was first described by Jaffe and Lichtenstein in 19421. It is considered a benign, locally aggressive lesion with a potential for local recurrence, and it typically appears in the metaphysis of the long bones and in the vertebral column2-4. Mostly, children and young adults are affected. No sex predilection has been observed. Radiographically, aneurysmal bone cyst is seen as a lytic lesion, usually eccentrically located and expansile but with well-defined margins. Histologically, there are blood-filled cysts separated by fibrous septa, with fibroblasts as well as osteoclast-type giant cells and reactive woven bone5. Historically, aneurysmal bone cyst was believed to occur exclusively in bone6. In 1972, Salm and Sissons noted soft-tissue lesions resembling aneurysmal bone cysts, and this was probably the first description of this entity7. For many years, aneurysmal bone cyst was thought to be a lesion, reactive in nature, caused by a circulatory abnormality leading to an increased venous pressure and resulting in dilation of the vascular network2,8,9. In recent years, strong evidence has supported the neoplastic nature of aneurysmal bone cyst10-13. In 1999, Panoutsakopoulos et al.10 demonstrated chromosomal translocation t(16;17)(q22;p13) as a recurrent cytogenetic abnormality in primary aneurysmal bone cyst, which was confirmed by other groups11-13. We report two cases of soft-tissue aneurysmal bone cyst with USP6 locus rearrangement on chromosome 17p13. The patients were informed that data concerning their cases would be submitted for publication, and they consented.
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