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Osteochondral Lesions of the Knee: A New One-Step Repair Technique with Bone-Marrow-Derived Cells
Roberto Buda, MD1; Francesca Vannini, MD, PhD1; Marco Cavallo, MD1; Brunella Grigolo, PhD1; Annarita Cenacchi, MD1; Sandro Giannini, MD1
1 II Clinic of Orthopaedics and Traumatology (R.B., F.V., M.C., and S.G.), Laboratory of Immunorheumatology and Tissue Regeneration (B.G.), and Service of Immunohematology and Transfusional Medicine (A.C.), Rizzoli Orthopaedic Institute, Via G.C. Pupilli 1, 40136, Bologna, Italy. E-mail address for F. Vannini: france_vannini@yahoo.it
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

Copyright © 2010 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2010 Dec 01;92(Supplement 2):2-11. doi: 10.2106/JBJS.J.00813
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Osteochondral lesions of the knee are defects of the cartilaginous surface and underlying subchondral bone, most frequently traumatic in origin1. These lesions are predominantly located on the medial femoral condyle, and associated ligamentous or meniscal pathology is reported in 40% of cases2,3 (Fig. 1). Biomechanical studies have demonstrated increased stress concentration on the rim of the osteochondral defect, which may have important implications for cartilage longevity4. Due to poor hyaline cartilage repair capability, larger osteochondral lesions of the knee are associated both with immediate significant clinical impairment and with symptoms appearing approximately one decade earlier than the degenerative cartilage changes that are associated with idiopathic osteoarthritis5.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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