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Bilateral Pathologic Hip Fractures Associated with Antiretroviral TherapyA Case Report
Brian J. Rebolledo, BA1; Aasis Unnanuntana, MD3; Joseph M. Lane, MD2
1 Weill Cornell Medical College, Cornell University, 1300 East 70th Street, New York, NY 10021. E-mail address: bjr2004@med.cornell.edu
3 Department of Orthopaedic Surgery, Siriraj Hospital, Mahidol University, 2 Prannok Street, Bangkok Noi District, Bangkok, Thailand 10700
2 Department of Orthopaedic Surgery, Hospital for Special Surgery, 535 East 71st Street, New York, NY 10021
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Disclosure: None of the authors received payments or services, either directly or indirectly (i.e., via his or her institution), from a third party in support of any aspect of this work. One or more of the authors, or his or her institution, has had a financial relationship, in the thirty-six months prior to submission of this work, with an entity in the biomedical arena that could be perceived to influence or have the potential to influence what is written in this work. No author has had any other relationships, or has engaged in any other activities, that could be perceived to influence or have the potential to influence what is written in this work. The complete Disclosures of Potential Conflicts of Interest submitted by authors are always provided with the online version of the article.

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Investigation performed at the Department of Orthopaedic Surgery, Hospital for Special Surgery, New York, NY

Copyright © 2011 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2011 Jul 20;93(14):e78 1-6. doi: 10.2106/JBJS.J.00885
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The use of antiretroviral medications in patients with human immunodeficiency virus (HIV) is highly effective in reducing HIV-related morbidity and mortality1,2. While HIV-positive patients continue to live longer with antiretroviral medications, adverse effects of long-term treatment include dyslipidemia, diabetes mellitus, and abnormalities of bone metabolism3,4. Metabolic bone disorders are common in patients with HIV infection, and many patients have premature osteoporosis and an increased risk of fracture5,6. While the mechanism of skeletal fragility in these patients remains inconclusive, antiretroviral medications have been described as a factor contributing to bone loss3,7.
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