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Scientific Articles   |    
Radiation Therapy for Heterotopic Ossification Prophylaxis Acutely After Elbow TraumaA Prospective Randomized Study
Nady Hamid, MD1; Nomaan Ashraf, MD1; Michael J. Bosse, MD1; Patrick M. Connor, MD2; James F. Kellam, MD1; Stephen H. Sims, MD1; Douglass E. Stull, MD3; Kyle J. Jeray, MD4; Robert A. Hymes, MD5; Timothy J. Lowe, PhD1
1 Department of Orthopaedic Surgery, Carolinas Medical Center, 1616 Scott Avenue, Charlotte, NC 28203. E-mail address for N. Hamid: nady.hamid@carolinashealthcare.org
2 OrthoCarolina, 1025 Morehead Medical Plaza, Charlotte, NC 28204
3 1112 West 6th Street, Suite 124, Lawrence, KS 66044
4 Greenville Hospital System University Medical Center, 701 Grove Road, 2nd Floor Support Tower, Greenville, SC 29605
5 Inova Fairfax Hospital, 3300 Gallows Road, Falls Church, VA 22042
View Disclosures and Other Information
Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from the Orthopaedic Trauma Association and the Carolinas Medical Center Health Services Foundation. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

Investigation performed at Carolinas Medical Center, Charlotte, North Carolina

Copyright © 2010 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2010 Sep 01;92(11):2032-2038. doi: 10.2106/JBJS.I.01435
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Abstract

Background: 

Heterotopic ossification around the elbow can result in pain, loss of motion, and impaired function. We hypothesized that a single dose of radiation therapy could be administered safely and acutely after elbow trauma, could decrease the number of elbows that would require surgical excision of heterotopic ossification, and might improve clinical results.

Methods: 

A prospective randomized study was conducted at three medical centers. Patients with an intra-articular distal humeral fracture or a fracture-dislocation of the elbow with proximal radial and/or ulnar fractures were enrolled. Patients were randomized to receive either single-fraction radiation therapy of 700 cGy immediately postoperatively (within seventy-two hours) or nothing (the control group). Clinical and radiographic assessment was performed at six weeks, three months, and six months postoperatively. All adverse events and complications were documented prospectively.

Results: 

This study was terminated prior to completion because of an unacceptably high number of adverse events reported in the treatment group. Data were available on forty-five of the forty-eight patients enrolled in this study. When the rate of complications was investigated, a significant difference was detected in the frequency of nonunion between the groups. Of the nine patients who had a nonunion, eight were in the treatment group. The nonunion rate was 38% (eight) of twenty-one patients in the treatment group, which was significantly different from the rate of 4% (one) of twenty-four patients in the control group (p = 0.007). There were no significant differences between the groups with regard to the prevalence of heterotopic ossification, postoperative range of motion, or Mayo Elbow Performance Score noted at the time of study termination.

Conclusions: 

This study demonstrated that postoperative single-fraction radiation therapy, when used acutely after elbow trauma for prophylaxis against heterotopic ossification, may play a role in increasing the rate of nonunion at the site of the fracture or an olecranon osteotomy. The clinical efficacy of radiation therapy could not be determined on the basis of the sample size. Further research is needed to determine the role of limited-field radiation for prophylaxis against heterotopic ossification after elbow trauma.

Level of Evidence: 

Therapeutic Level I. See Instructions to Authors for a complete description of levels of evidence.

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    Accreditation Statement
    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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