0
Commentary and Perspective   |    
Commentary on an Article by Martha M. Murray, MD, et al.: “The Effect of Skeletal Maturity on Functional Healing of the Anterior Cruciate Ligament”
Mark R. Hutchinson, MD
View Disclosures and Other Information
The author did not receive any outside funding or grants in support of his research for or preparation of this work. Neither he nor a member of his immediate family received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

Copyright © 2010 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2010 Sep 01;92(11):e15 1-1. doi: 10.2106/JBJS.J.00940
The main article is available here
5 Recommendations (Recommend) | 3 Comments | Saved by 3 Users Save Case
text A A A
Dr. Murray and her colleagues have created an elegant, in vitro, animal study that helps to clarify some of the key questions regarding the effect of age and specific technique on repair of the anterior cruciate ligament. The porcine animal model, while not directly translatable to humans, allows us a more effective opportunity to evaluate histological and clinical healing of the ligament repair tissue.
Historically, surgeons have all but discarded the use of primary repair in addressing anterior cruciate ligament injuries unless the ligament is avulsed from its origin or insertion. The outcomes have been substantially better with reconstruction than with repair in adults. The juvenile and adolescent population introduces the unique challenges of reconstructing cruciate ligaments across open physes, with the risk of premature physeal closure. Therefore, many clinicians have elected to accept the risk of additional meniscal injury and wait until the patient achieves skeletal maturity before proceeding with reconstruction. If there were a better way to repair a torn anterior cruciate ligament in the juvenile and adolescent population, it could change the current treatment algorithm.
The authors of this paper transected the anterior cruciate ligaments of both knees in the porcine model, leaving one to heal on its own as the control and repairing the other with an enhanced suture repair technique, combined with the use of collagen platelet composite. I would have liked to have seen a third group to compare the results of suture repair alone without the collagen matrix added, but this was not done in the study. Nonetheless, the authors report some very important findings. In this study, the younger the animal, the better the result with use of suture repair with their augmented suture technique. At the time of follow-up, the tissue is stronger and histologically more viable. In the adult animals, there was a poorer quality of repair and secondary global capsular thickening that provided a pseudostability of the knee by increasing the overall stiffness.
As is the case with all animal studies, it is not clear how these findings will extrapolate to humans. Nonetheless, the findings in this porcine model give a reason for excitement as we look toward the future in addressing anterior cruciate ligament instability, particularly in the skeletally immature individual.

Submit a comment

References

Accreditation Statement
These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
CME Activities Associated with This Article
Submit a Comment
Please read the other comments before you post yours. Contributors must reveal any conflict of interest.
Comments are moderated and will appear on the site at the discretion of JBJS editorial staff.

* = Required Field
(if multiple authors, separate names by comma)
Example: John Doe





Related Content
The Journal of Bone & Joint Surgery
JBJS Case Connector
Topic Collections
Related Audio and Videos
PubMed Articles
Clinical Trials
Readers of This Also Read...
JBJS Jobs
01/08/2014
Pennsylvania - Penn State Milton S. Hershey Medical Center
02/05/2014
Oregon - The Center - Orthopedic and Neurosurgical Care and Research
04/16/2014
Ohio - OhioHealth Research and Innovation Institute (OHRI)