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Extreme EnchondromatosisA Report of Two Cases and Review of the Literature
Andrew Ghatan, MD1; Thomas Scharschmidt, MD2; Ernest Conrad, MD1
1 Department of Orthopaedic Surgery, Seattle Children's Hospital, 4800 Sand Point Way N.E., Seattle, WA 98105
2 Department of Orthopaedic Surgery, The Ohio State University, 2050 Kenny Road, Suite 3300, Columbus, OH 43221. E-mail address: Thomas.scharschmidt@osumc.edu
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Disclosure: In support of their research for or preparation of this work, one or more of the authors received, in any one year, outside funding or grants in excess of $10,000 from Northwest Tissue Services and Zimmer. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

Investigation performed at Seattle Children's Hospital, Seattle, Washington

Copyright © 2010 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2010 Oct 06;92(13):2336-2343. doi: 10.2106/JBJS.J.00194
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Enchondromatosis is a rare disorder characterized by anomalous enchondral ossification leading to multifocal hyperplastic cartilaginous enchondromas that usually affect the diaphysis or metaphysis of long bones. Although previously known by various names, it is perhaps best known as Ollier disease, named for the physician who first described it in 18981,2. The understanding of this disease has evolved, so that there are now numerous subtypes that differ according to the various clinical and radiographic findings associated with multiple enchondromas. A review of the literature suggests that enchondromatosis may not have a typical uniform pattern of clinical appearance3-12.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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    Vijay Kumar Jain
    Posted on February 11, 2011
    Department of Orthopedics, PGIMER, Dr. Ram Manohar Lohia Hospital, New Delhi, India

    To the Editor:

    We have read an article entitled, "Extreme Enchondromatosis A Report of Two Cases and Review of the Literature" written by Andrew Ghatan, Thomas Scharschmidt, and Ernest Conrad (2010;92:2336-43). I found this paper very interesting and useful for extreme enchondromatosis. The authors reported a case of a 5 month old child and stated this to be youngest reported to date. We reviewed the literature and found a case of neonatal enchondromatosis (1). This female patient was born at the 33rd week of gestation and presented with typical clinical features and radiological changes at birth. This case should also be included in this paper as being youngest reported case so far.


    1. Raupp P, Kemperdick H. Neonatal radiological aspect of enchondromatosis (Ollier's disease). Pediatr Radiol. 1990;20:337-8.

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