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Isolated Cardiac Metastasis from a Histologically “Benign” Giant-Cell Tumor of the Distal End of the FemurA Case Report
Qing Zhang, MD1; Haitao Zhao, MD1; Aditya V. Maheshwari, MD2; Lei Cai, MD1; Feng Yu, MD1; Xiaohui Niu, MD1
1 Departments of Orthopedic Oncology (Q.Z., H.Z., F.Y., and X.N.) and Pathology (L.C.), Beijing Ji Shui Tan Hospital, Peking University, 31 Xinjiekou East Street, Xicheng District, Beijing, China 100035. E-mail address for X. Niu: zhuomaxixi@163.com
2 Department of Orthopaedic Oncology, Washington Hospital Center, 110 Irving Street N.W., Washington, DC 20010
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

Investigation performed at the Departments of Orthopedic Oncology and Pathology, Peking University, Beijing, China

Copyright © 2010 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2010 Nov 17;92(16):2725-2731. doi: 10.2106/JBJS.J.00042
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Although classified as a benign lesion, giant cell tumor of bone is known for its local aggressiveness, propensity for local recurrence, and metastasis even without sarcomatous transformation1-13. The frequency of metastases from benign giant-cell tumor of bone has been reported to range from 2% to 9% in larger series2-10. Most metastases are to the lungs, but metastases to the endobronchium, lymph nodes (regional as well as mediastinum and paraaortic), bone, skin, scalp, calf muscles, brain, liver, adrenals, kidneys, and breast have been reported1-25. We present the case of a patient with a benign giant-cell tumor of the distal end of the femur who subsequently developed an isolated cardiac metastasis. To the best of our knowledge, a cardiac metastasis from a benign giant-cell tumor has never been reported. The family members of our patient were informed that data concerning the case would be submitted for publication, and they consented.
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