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Monostotic Fibrous Dysplasia of the SpineA Report of Seven Cases
Andrew J. Schoenfeld, MD1; Stephanie A. Koplin, MD1; Ron Garcia, BS1; Francis J. Hornicek, MD, PhD1; Henry J. Mankin, MD1; Kevin A. Raskin, MD1; Dempsey Springfield, MD1; Andrew E. Rosenberg, MD1; Joseph H. Schwab, MD, MS1
1 Departments of Orthopaedic Surgery (A.J.S., R.G., F.J.H., H.J.M., K.A.R., D.S., and J.H.S.) and Pathology, WRN 225 (S.A.K. and A.E.R.), Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. One or more of the authors, or a member of his or her immediate family, received, in any one year, payments or other benefits in excess of $10,000 or a commitment or agreement to provide such benefits from commercial entities (Stryker and Zimmer).

Investigation performed at the Departments of Orthopaedic Surgery and Pathology, Massachusetts General Hospital, Boston, Massachusetts

Copyright ©2010 American Society for Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2010 Apr 01;92(4):984-988. doi: 10.2106/JBJS.I.00727
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Monostotic fibrous dysplasia of the spine is rare, with the cases of fewer than thirty-five patients discussed in the literature. Dahlin and Unni reviewed the cases of 418 patients with monostotic fibrous dysplasia and noted six (1.4%) involving the spine1. In a series reported by Harris et al., one patient with spine involvement was noted in a total of thirteen patients with monostotic fibrous dysplasia2. Most reports have described the case of a single patient with minimal to no follow-up1-23. As a result, the natural history and ideal treatment for this condition remain poorly understood. For example, the prevalence of scoliosis in patients with polyostotic fibrous dysplasia has been found to be up to 40%24, whereas scoliosis in monostotic fibrous dysplasia appears to be quite rare25. The reported treatment of monostotic fibrous dysplasia in the spine also has varied widely, from surgical resection4,5,7,9-19 to biopsy and observation2,21.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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