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Case Reports   |    
Transmission of Elizabethkingia meningoseptica (Formerly Chryseobacterium meningosepticum) to Tissue-Allograft RecipientsA Report of Two Cases
Emily J. Cartwright, MD1; Rajesh M. Prabhu, MD2; Craig E. Zinderman, MD, MPH3; William E. Schobert, MD4; Bette Jensen, MMSc1; Judith Noble-Wang, PhD1; Kelly Church, MD1; Cindi Welsh2; Matthew Kuehnert, MD1; Timothy L. Burke, MD2; Arjun Srinivasan, MD1;
1 Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, 1600 Clifton Road, MS A35, Atlanta, GA 30333. E-mail address for A. Srinivasan: asrinivasan@cdc.gov
2 Departments of Infectious Diseases and Infection Control, SMDC Health System, 400 East 3rd Street, Duluth, MN 55805
3 Office of Epidemiology, Center for Biologics Evaluation and Research, Food and Drug Administration, 1401 Rockville Pike HFM-220, Rockville, MD 20852
4 26020 Acero, Suite 100, Mission Viejo, CA 92691
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

The Food and Drug Administration Tissue Safety Team Investigators are Hang Dinh, Melissa Greenwald, MD, Laura St. Martin, MD, and Ruth Solomon, MD.
Disclaimer: The findings and conclusions in this report reflect those of the authors and do not necessarily reflect the official opinion of the Centers for Disease Control and Prevention or the Food and Drug Administration.

Copyright ©2010 American Society for Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2010 Jun 01;92(6):1501-1506. doi: 10.2106/JBJS.I.00502
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Extract

According to the American Association of Tissue Banks, over 1.5 million allografts are distributed annually in the United States1. Recent incidents involving the distribution of human tissues from donors not properly screened for infectious diseases have highlighted concerns for disease transmission through transplanted tissues2-4. Although rarely reported, allograft-associated infections have been associated with a variety of organisms and tissue types4. In all of the previously published reports, organisms were transmitted from the donor, because of either an unrecognized infection or contamination during tissue recovery. However, in the fall of 2006, we investigated the cases of two patients who had allograft-associated surgical site infections caused by Elizabethkingia meningoseptica (formerly Chryseobacterium meningosepticum), detected by orthopaedic surgeons, that may have been the result of environmental contamination at one firm during processing of tissues from different donors.
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