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Myxoid Chondrosarcoma of the Phalanx with an EWS TranslocationA Case Report and Review of the Literature
David B. Bumpass, MD1; Michael Kyriakos, MD1; David A. Rubin, MD1; Paul R. Manske, MD1; Charles A. Goldfarb, MD1
1 Department of Orthopaedic Surgery (D.B.B., P.R.M., and C.A.G.), Surgical Pathology (M.K.), and Radiology (D.A.R.), Washington University School of Medicine, 660 South Euclid, Campus Box 8233, St. Louis, MO 63110. E-mail address for C.A. Goldfarb: goldfarbc@wustl.edu
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Disclosure: The authors did not receive any outside funding or grants in support of their research for or preparation of this work. Neither they nor a member of their immediate families received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity.

Investigation performed at the Departments of Orthopaedic Surgery, Surgical Pathology, and Radiology, Washington University School of Medicine, Saint Louis Shriners Hospital and Barnes-Jewish Hospital, St. Louis, Missouri

Copyright © 2011 by The Journal of Bone and Joint Surgery, Inc.
J Bone Joint Surg Am, 2011 Mar 16;93(6):e23 1-7. doi: 10.2106/JBJS.J.00520
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Myxoid chondrosarcoma is a histologically and genetically distinct tumor that predominantly originates in soft tissue, unlike conventional chondrosarcoma, which arises primarily in bone1-3. Several hundred cases of extraskeletal myxoid chondrosarcoma have been reported, but true intraosseous myxoid chondrosarcoma tumors have rarely been reported. Several nonrandom chromosomal translocations, most commonly t(9;22) EWS-CHN, have been identified in extraskeletal myxoid chondrosarcoma4,5. These translocations can help with diagnosis; however, to date, no such translocation has been identified in an unequivocal skeletal myxoid chondrosarcoma tumor, leading previous authors to conclude that skeletal and extraskeletal myxoid chondrosarcoma tumors are separate and distinct entities6,7. We present the case of a patient with myxoid chondrosarcoma with both a clear skeletal origin and an EWS-containing chromosomal translocation, thus providing evidence that the skeletal and extraskeletal forms of myxoid chondrosarcoma represent the same pathologic entity. The patient was informed that data concerning the case would be submitted for publication, and she consented.
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    These activities have been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of the American Academy of Orthopaedic Surgeons and The Journal of Bone and Joint Surgery, Inc. The American Academy of Orthopaedic Surgeons is accredited by the ACCME to provide continuing medical education for physicians.
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