Flow diagram of study population exclusions and inclusions. ATB = at time of bombings.

Percent improvement in radiographic parameters over time is shown graphically with statistical comparisons between groups. Individual p values for TCP and TCP/BM reflect the significant changes over time for each parameter in each group. P values for TCP versus TCP/BM reflect differences between the two groups, which were not significant for any of the parameters. TCP = ultraporous β-tricalcium phosphate alone, and TCP/BM = ultraporous β-tricalcium phosphate combined with bone marrow aspirate.

A type-II wide intracompartmental resection includes removing the proximal part of the fibula along with 6 to 7 cm of normal diaphysis, the anterolateral muscle compartments, the peroneal nerve, and the anterior tibial artery. Ex dig. longus m. = extensor digitorum longus muscle.

Change in mean surgery-type designation by the four faculty surgeons assessing the blinded pre-chemotherapy and post-chemotherapy MRIs. Surgery-type designations were converted to integers one through four and averaged for each case at each time point. While some remained unchanged, others changed following administration of neoadjuvant chemotherapy toward either more or less radical/risky resections. (Multiple parallel lines are drawn at slight vertical offsets when values overlap, such that a single line represents each case.)

Referral time (days from the first visit to a physician until referral to the sarcoma center) according to whether the referral pathway was through the local hospital or directly to the sarcoma center (SC).

Distribution of the eighty-five chondrosarcomas in the appendicular long bones. The proximal part of the humerus and the distal part of the femur were most frequently affected.

Parameters on cephalometric radiograph are measured for evaluation of the craniofacial deformity: skull-base tilting angle (SBTA) (Fig. 1-A), craniofacial tilting angle (CFTA) (Fig. 1-B), transverse calvarial asymmetry (TCA) (Fig. 1-C), transverse skull-base asymmetry (TSBA) (Fig. 1-D), and mastoid-process length ratio (MPLR) (Fig. 1-E). Wa = width of the affected side, Wc = width of the contralateral side, La = length of the affected side, Lc = length of the contralateral side.

Series cases map for the original 621 cases of giant cell tumor (GCT). MSTS = Musculoskeletal Tumor Society.

Chordoma-specific survival by treatment group, with 0 (purple) indicating neither surgery nor radiation; 1 (red), surgery only; 2 (green), radiation only; and 3 (brown), both surgery and radiation; the difference was significant (p = 0.03).

The association between clinical phenotype and the disease-linked gene (Fig. 1-A), sex (Fig. 1-B), sporadic origin or family history (Fig. 1-C), and number of skeletal sites with exostoses (Fig. 1-D). The bars indicate the percentage of patients. M = male, and F = female.