Factors in the Pathogenesis of Non-Union
JAMES B. WRAY

Abstract

Delayed union or non-union is most frequently encountered in the young adult who has suffered a severe long-bone fracture that is associated with extensive tissue destruction or infection.

While our knowledge of the normal fracture-healing process is incomplete, enough information exists to suggest that non-unions are of local origin and are the result of defective formation or vascularization of the fracture callus.

Although our present understanding of the mechanisms of mineral deposition is too limited to permit anything but speculation concerning the possible role of defects in these mechanisms in non-union, available information suggests that such defects are not important causes of non-union.