Rate of Improvement Was Not Different After Osteochondral Repair with Matrix-Induced Autologous Chondrocyte Implantation or Autologous Chondrocyte Implantation with a Cover Made from Porcine-Derived Type I/Type III Collagen


Question: In patients having repair of osteochondral defects in the knee, how does the matrix-induced autologous chondrocyte implantation (MACI) technique compare with autologous chondrocyte implantation with a cover manufactured from porcine-derived type I/type III collagen (ACI-C)?

Design: Randomized (allocation concealed)*, unblinded, controlled trial with 1-year follow-up.

Setting: A hospital in Middlesex, England, United Kingdom.

Patients: 91 patients who were 15 to 50 years of age (mean age, 33 y; 59% men), had an isolated osteochondral defect >1 cm2, and could follow a rehabilitation program. Patients with osteoarthritis …

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