Wear Particles
Joshua J. Jacobs, MD; Nadim J. Hallab, PhD; Robert M. Urban ; Markus A. Wimmer, PhD


Particulate and ionic debris resulting from in vivo degradation of total joint replacement components are recognized as major factors limiting the longevity of the joint reconstruction and the overall success of the procedure. Particulate and ionic wear and corrosion debris have been associated with a locally aggressive biologic response that can lead to synovitis, periprosthetic bone loss, and aseptic loosening of the implants. Furthermore, concerns exist regarding the systemic dissemination of prosthetic debris, including potential effects resulting from end-organ retention. The long-term success of total disc arthroplasty may well depend, at least in part, on the ability to minimize implant debris generation and the subsequent local and systemic response.


  • In support of their research for or preparation of this manuscript, one or more of the authors received grants or outside funding from Zimmer Inc., Wright Medical, Medtronics, the National Institutes of Health (the National Institute of Arthritis and Musculoskeletal and Skin Diseases), DePuy, and Smith and Nephew. In addition, one or more of the authors received payments or other benefits or a commitment or agreement to provide such benefits from a commercial entity (Zimmer Inc., Wright Medical, Medtronics, Archus Orthopaedics, DePuy, and Smith and Nephew). Also, a commercial entity (Zimmer Inc., Wright Medical, Medtronics, and DePuy) paid or directed, or agreed to pay or direct, benefits to a research fund, foundation, educational institution, or other charitable or nonprofit organization with which the authors are affiliated or associated.

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