RT Journal
A1 Shore, Benjamin J.
A1 Nasreddine, Adam Y.
A1 Kocher, Mininder S.
T1 Overcoming the Funding Challenge: The Cost of Randomized Controlled Trials in the Next Decade
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2012
FD July 18
VO 94
IS Suppl 1(E)
SP 101
OP 106
DO 10.2106/JBJS.L.00193
UL http://dx.doi.org/10.2106/JBJS.L.00193
AB Abstract: 
  Randomized controlled trials (RCTs) represent the gold standard of evidence-based medicine. However, over the last several decades, the cost associated with conducting RCTs has increased dramatically. Several factors contribute to higher costs associated with clinical trials. This paper describes important barriers to conducting surgical RCTs, identifies funding sources available to finance RCTs, and suggests strategies to maintain cost-efficient study practices as we move into the next decade.