RT Journal
A1 Pullenayegum, Eleanor M.
T1 Adaptive Bayesian Randomized Trials: Realizing Their Potential
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2012
FD July 18
VO 94
IS Suppl 1(E)
SP 29
OP 33
DO 10.2106/JBJS.L.00094
UL http://dx.doi.org/10.2106/JBJS.L.00094
AB Abstract: 
  Bayesian adaptive designs offer the flexibility to adapt the conduct of a trial in response to accumulating evidence. This ability of the trial to adapt is especially appealing when studying an intervention that evolves rapidly. Examples of design adaptations include dropping arms from a study, sample size re-estimation, or stopping a trial early. The choice of adaptive design must match the objectives of the trial, and this paper gives examples of designs suitable for exploratory trials, explanatory trials, and trials assessing cost-effectiveness.