RT Journal
A1 Sibai, Tarek
A1 Carlisle, Hope
A1Tornetta, III ,Paul
T1 The Darker Side of Randomized TrialsRecruitment Challenges
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2012
FD July 18
VO 94
IS Suppl 1(E)
SP 49
OP 55
DO 10.2106/JBJS.L.00240
UL http://dx.doi.org/10.2106/JBJS.L.00240
AB Abstract: 
  Randomized trials are thought to provide optimal evidence if carried out correctly. Their application to important questions is the best guide to clinical decision-making. However, these trials are expensive to complete and have a variety of challenges in design and application. This article will review some of the factors that affect our ability to recruit patients into randomized controlled trials for conditions that may be treated surgically by different methods or for conditions for which both nonsurgical and surgical treatments exist.