RT Journal
A1 Hoaglund, Franklin T.
T1 Primary Osteoarthritis of the Hip: A Genetic Disease Caused by European Genetic Variants
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2013
FD March 6
VO 95
IS 5
SP 463
OP 468
DO 10.2106/JBJS.L.00077
UL http://dx.doi.org/10.2106/JBJS.L.00077
AB ➤ Primary osteoarthritis of the hip is a separate phenotype that occurs at a rate of 3% to 6% in the populations of the world with European ancestry.➤ In all non-European populations, there is a consistent rarity of primary osteoarthritis that suggests a different etiology for these few patients.➤ Family, sibling, and twin studies prove primary osteoarthritis to be a genetic disease with a 50% heritability caused by European genetic variants.➤ The genetic basis is reinforced by the lower rate of primary osteoarthritis in American minorities consistent with their degree of European gene admixture.➤ Whether the mechanism of degeneration of primary osteoarthritis may be secondary through a morphologic deformity, such as femoroacetabular impingement, remains unknown.➤ The virtual absence of the disease in non-Europeans indicates that the European gene component is necessary for the expression of this separate phenotype of osteoarthritis.