RT Journal
A1 Gulotta, Lawrence V.
A1 Wiznia, Daniel
A1 Cunningham, Matthew
A1 Fortier, Lisa
A1 Maher, Suzanne
A1 Rodeo, Scott A.
T1 What's New in Orthopaedic Research
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2011
FD November 16
VO 93
IS 22
SP 2136
OP 2141
DO 10.2106/JBJS.K.00981
UL http://dx.doi.org/10.2106/JBJS.K.00981
AB 
Over the last year, our understanding of the biological basis of orthopaedic pathology and its treatments has expanded. Particular attention continues to be directed toward the role of stem cells for tissue regeneration as well as the role of growth factors for healing augmentation. Substantial advances have also been made in our understanding of the response of stem cells to load, topography, and growth factors. While bench research is promising, recent clinical studies, specifically, those on the use of platelet-rich plasma (PRP), haven fallen short of expectations. The exact reasons for the disconnect between promising basic science research and discouraging clinical results is most likely multifactorial, and further research is needed to identify the various factors critical for success.