RT Journal
A1 Hunt, D. M.
A1 Holmes, Z.
A1 Pickering, W.
A1 Cohen, H.
A1 Glueck, C. J.
A1 Freiberg, Richard
A1 Crawford, Alvin
A1 Roy, Dennis
A1 Glueck, Helen
A1 Stroop, Davis
T1 Correspondence
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 1998
FD April 1
VO 80
IS 4
SP 604
OP b
DO 
UL http://dx.doi.org/
AB 
    The etiology of Legg-Perthes disease is poorly understood, but recent reports have suggested a strong association with heritable thrombophilic defects. Glueck et al., in their study "Association of Antithrombotic Factor Deficiencies and Hypofibrinolysis with Legg-Perthes Disease" (78-A: 3—13, Jan. 1996), reported that 59 per cent (twenty-six) of forty-four children who had Legg-Perthes disease had a thrombophilic defect: nineteen (43 per cent) had protein-C deficiency, four (9 per cent) had protein-S deficiency, and three (7 per cent) had hypofibrinolysis. As part of an ongoing, unpublished study, we screened twelve white individuals who had Legg-Perthes disease for heritable thrombophilic defects. The ten male and two female patients had a median age of eleven years (range, six to forty-three years). None of the individuals had a personal or family history of thromboembolism.