RT Journal A1 Lane, Joseph M. T1 Dynamics of Bone and Cartilage Metabolism. JF The Journal of Bone & Joint Surgery JO The Journal of Bone & Joint Surgery YR 2001 FD April 1 VO 83 IS 4 SP 639 OP a DO UL http://dx.doi.org/ AB The book is divided into three sections. The first section covers the components of the organic extracellular matrix of bone and cartilage and includes a detailed discussion of collagen and growth factors. The second section is devoted to the structure and metabolism of the extracellular matrix, including the cells and the matrix and hormones regulating bone and cartilage. The third section addresses markers of bone and cartilage metabolism in normal individuals and in those who have common diseases, such as osteoporosis, osteomalacia, rheumatoid arthritis, osteoarthritis, and growth disorders. The Basic Science book and the Orthopaedic Knowledge Updates produced by the American Academy of Orthopaedic Surgeons contain only brief mention of the underlying pathophysiology of bone and cartilage diseases, whereas the current book offers a broad discussion of the full pathophysiology of common musculoskeletal disorders.