RT Journal
A1 Jacobs, Joshua J.
A1 Hallab, Nadim J.
A1 Urban, Robert M.
A1 Wimmer, Markus A.
T1 Wear Particles
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2006
FD April 1
VO 88
IS suppl_2
SP 99
OP 102
DO 10.2106/JBJS.F.00102
UL http://dx.doi.org/10.2106/JBJS.F.00102
AB Particulate and ionic debris resulting from in vivo degradation of total
joint replacement components are recognized as major factors limiting the
longevity of the joint reconstruction and the overall success of the
procedure. Particulate and ionic wear and corrosion debris have been
associated with a locally aggressive biologic response that can lead to
synovitis, periprosthetic bone loss, and aseptic loosening of the implants.
Furthermore, concerns exist regarding the systemic dissemination of prosthetic
debris, including potential effects resulting from end-organ retention. The
long-term success of total disc arthroplasty may well depend, at least in
part, on the ability to minimize implant debris generation and the subsequent
local and systemic response.