RT Journal A1 Zalavras, Charalampos G. A1 Femino, Dominic A1 Triche, Rachel A1 Zionts, Lewis A1 Stevanovic, Milan T1 Reconstruction of Large Skeletal Defects Due to Osteomyelitis with the Vascularized Fibular Graft in Children JF The Journal of Bone & Joint Surgery JO The Journal of Bone & Joint Surgery YR 2007 FD October 1 VO 89 IS 10 SP 2233 OP 2240 DO 10.2106/JBJS.E.01319 UL http://dx.doi.org/10.2106/JBJS.E.01319 AB Background: Reconstruction of large skeletal defects secondary to osteomyelitis is a challenging problem. The purpose of this study was to evaluate the outcome of the use of a vascularized fibular graft to treat such defects in children.Methods: Eight patients with a mean age of seven years and a skeletal defect with a mean length of 11.8 cm (range, 6 to 17 cm) were treated with a vascularized fibular graft. A staged protocol was used for the five patients with an active infection at the time of presentation. The first procedure consisted of radical débridement, and at the second stage a free (seven patients) or pedicled (one patient) vascularized fibular graft was used. The mean follow-up time was 5.7 years.Results: Union of the graft occurred primarily in seven of the eight patients, at a mean of 3.5 months, and after iliac crest bone-grafting in the remaining patient. There was no recurrence of deep infection. Complications developed in two patients. The mean time to full weight-bearing by the seven patients with a lower-extremity reconstruction was 8.4 months, and all patients were pain-free and able to walk without supportive devices.Conclusions: A vascularized fibular graft is a viable option for the management of large skeletal defects resulting from osteomyelitis in children.Level of Evidence: Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.