RT Journal A1 Rogers, Benedict A. A1 Ricketts, David M. T1 Can Vitamin C Prevent Complex Regional Pain Syndrome in Patients with Wrist Fractures? JF The Journal of Bone & Joint Surgery JO The Journal of Bone & Joint Surgery YR 2008 FD February 1 VO 90 IS 2 SP 447 OP 448 DO UL http://dx.doi.org/ AB The paper cites an article by Kearns et al.1 to provide the steady-state level of ascorbic acid (vitamin C) with doses of 200 mg per day. However, Kearns et al. used Sprague-Dawley rats in their study. The muscles were analyzed after three hours of ischemia and one hour of reperfusion. We are not convinced that these data can be used to accurately determine the steady-state level of vitamin C in humans.