RT Journal
A1 Darouiche, Rabih O.
T1 In Vivo Efficacy of Antimicrobial-Coated Devices
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2008
FD August 1
VO 90
IS 8
SP 1785
OP 1786
DO 
UL http://dx.doi.org/
AB 
I appreciate the concern by Dr. Neogi and colleagues for the potential development of rifampin resistance among agents of tuberculosis in scenarios where systemic antituberculous medications are suboptimally used. However, this potential concern does not necessarily imply that rifampin resistance is likely to occur among mycobacterial or bacterial organisms, including staphylococci, in patients who receive devices coated with the optimal combination of rifampin and minocycline. In fact, several clinical studies have shown no evidence for the development of rifampin resistance among bacterial organisms, including staphylococci, in patients who receive rifampin-minocycline-coated vascular catheters1-3.