RT Journal
A1 Welsch, Goetz H.
A1 Trattnig, Siegfried
A1 Tichy, Brigitte
A1 Mamisch, Tallal C.
A1 Wondrasch, Barbara
A1 Marlovits, Stefan
T1 Tibial Cartilage Hypertrophy Due to Matrix-Associated Autologous Chondrocyte Transplantation of the Medial Femoral CondyleA Case Report
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2009
FD August 1
VO 91
IS 8
SP 1996
OP 2001
DO 10.2106/JBJS.H.01180
UL http://dx.doi.org/10.2106/JBJS.H.01180
AB 
Osteochondral graft hypertrophy is commonly seen after autologous chondrocyte transplantation with use of a periosteal flap1,2. Reoperation may be performed because of a high grade of hypertrophy causing persistent clinical symptoms. The use of a collagen membrane to cover the chondrocyte suspension can reduce the risk of graft hypertrophy3,4. Further technological advances have led to a third generation of autologous chondrocyte transplantation with use of biomaterials seeded with chondrocytes as so-called all-in-one scaffolds that generate new articular cartilage5. Nevertheless, graft hypertrophy continues to occur, although the prevalence has been reduced with matrix-associated autologous chondrocyte transplantation6,7.