RT Journal
A1 Mishima, Kenichi
A1 Kitoh, Hiroshi
A1 Katagiri, Takenobu
A1 Kaneko, Hiroshi
A1 Ishiguro, Naoki
T1 Early Clinical and Radiographic Characteristics in Fibrodysplasia Ossificans ProgressivaA Report of Two Cases
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2011
FD May 18
VO 93
IS 10
SP e52 1
OP 5
DO 10.2106/JBJS.J.01443
UL http://dx.doi.org/10.2106/JBJS.J.01443
AB 
Fibrodysplasia ossificans progressiva is an extremely rare and disabling genetic condition characterized by progressive heterotopic ossification of soft tissues such as muscles, ligaments, tendons, fasciae, and aponeuroses. The prevalence of fibrodysplasia ossificans progressiva is estimated to be about one in 2 million individuals1. Heterotopic ossification in fibrodysplasia ossificans progressiva usually begins in the first decade of life with the episodic development of inflammatory fibroproliferative masses in the axial skeleton. Most patients with fibrodysplasia ossificans progressiva are misdiagnosed as having soft-tissue sarcoma or aggressive juvenile fibromatosis before the definitive appearance of heterotopic ossification and undergo invasive procedures that usually lead to the acceleration of ossification2. Early correct diagnosis of fibrodysplasia ossificans progressiva is necessary to prevent additional iatrogenic harm or trauma.