RT Journal A1 Baumgarten, Keith M. T1 Commentary on an article by Jacob S. Vandermeer et al.: “Local Administration of Ibandronate and Bone Morphogenetic Protein-2 After Ischemic Osteonecrosis of the Immature Femoral Head. A Combined Therapy That Stimulates Bone Formation and Decreases Femoral Head Deformity” JF The Journal of Bone & Joint Surgery JO The Journal of Bone & Joint Surgery YR 2011 FD May 18 VO 93 IS 10 SP e57 1 OP 2 DO 10.2106/JBJS.K.00270 UL http://dx.doi.org/10.2106/JBJS.K.00270 AB Osteonecrosis of the immature femoral head is a condition that occurs spontaneously with Legg-Calvé-Perthes disease and after a traumatic insult from an unstable slipped capital femoral epiphysis, a femoral neck fracture, or a hip dislocation. Unfortunately, femoral head collapse and deformity are potential outcomes of this disorder. The severity of the residual femoral head deformity has been shown to be the most important prognostic indicator of long-term outcome, with severe cases requiring hip arthroplasty as early as the third decade of life.