RT Journal
A1 Pietschmann, Matthias F.
A1 Oliveira, Andre M.
A1 Chou, Margaret M.
A1 Ihrler, Stefan
A1 Niederhagen, Manuel
A1 Baur-Melnyk, Andrea
A1 Dürr, Hans Roland
T1 Aneurysmal Bone Cysts of Soft Tissue Represent True NeoplasmsA Report of Two Cases
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2011
FD May 4
VO 93
IS 9
SP e45 1
OP 8
DO 10.2106/JBJS.J.00534
UL http://dx.doi.org/10.2106/JBJS.J.00534
AB 
Aneurysmal bone cyst was first described by Jaffe and Lichtenstein in 19421. It is considered a benign, locally aggressive lesion with a potential for local recurrence, and it typically appears in the metaphysis of the long bones and in the vertebral column2-4. Mostly, children and young adults are affected. No sex predilection has been observed. Radiographically, aneurysmal bone cyst is seen as a lytic lesion, usually eccentrically located and expansile but with well-defined margins. Histologically, there are blood-filled cysts separated by fibrous septa, with fibroblasts as well as osteoclast-type giant cells and reactive woven bone5. Historically, aneurysmal bone cyst was believed to occur exclusively in bone6. In 1972, Salm and Sissons noted soft-tissue lesions resembling aneurysmal bone cysts, and this was probably the first description of this entity7. For many years, aneurysmal bone cyst was thought to be a lesion, reactive in nature, caused by a circulatory abnormality leading to an increased venous pressure and resulting in dilation of the vascular network2,8,9. In recent years, strong evidence has supported the neoplastic nature of aneurysmal bone cyst10-13. In 1999, Panoutsakopoulos et al.10 demonstrated chromosomal translocation t(16;17)(q22;p13) as a recurrent cytogenetic abnormality in primary aneurysmal bone cyst, which was confirmed by other groups11-13. We report two cases of soft-tissue aneurysmal bone cyst with USP6 locus rearrangement on chromosome 17p13. The patients were informed that data concerning their cases would be submitted for publication, and they consented.