RT Journal
A1 Kambic, Helen
T1 The Meniscus—A Key to Unfolding the Mystery of OsteoarthritisCommentary on an article by Robert H. Brophy, MD, et al.: “Molecular Analysis of Age and Sex-Related Gene Expression in Meniscal Tears with and without a Concomitant Anterior Cruciate Ligament Tear”
JF The Journal of Bone & Joint Surgery
JO The Journal of Bone & Joint Surgery
YR 2012
FD March 7
VO 94
IS 5
SP e31 1
OP 2
DO 10.2106/JBJS.K.01593
UL http://dx.doi.org/10.2106/JBJS.K.01593
AB 
Our appreciation of the molecular organization of the meniscus is leading to a greater understanding of its cellular function in disease. Meniscal tears can lead to knee osteoarthritis, but knee osteoarthritis can lead to a spontaneous meniscal tear through breakdown of the meniscal structure1. This study is timely and relevant regarding the predicted increase in the prevalence of new cases of osteoarthritis in the young athletic population of both sexes. The cross-reactivity of several molecular markers associated with osteoarthritis was demonstrated in the torn meniscus. Although the authors chose an age cutoff of forty years, the age at onset of meniscal injury influences the primary cellular response. Age-related changes coupled with tear location within the meniscus and contributions of the synovial fluid could influence gene expression.