TY  - JOUR
T1  - Use and Interpretation of Composite End Points in Orthopaedic Trials
AU  - Busse, Jason W.
AU  - Bhandari, Mohit
AU  - Ferreira-González, Ignacio
AU  - Montori, Victor M.
AU  - Guyatt, Gordon H.
Y1  - 2012/07/18
N1  - 10.2106/JBJS.K.01287
JO  - The Journal of Bone & Joint Surgery
SP  - 65
EP  - 69
VL  - 94
IS  - Suppl 1(E)
N2  - Abstract: 
  Randomized controlled trials in orthopaedics are often underpowered to detect important differences in outcomes. Composite end points (CEPs) hold promise as a strategy to address this issue by combining multiple end points into one summary measure, thus increasing the observed event rate. The use of CEPs by trialists, however, can be problematic when they include components that vary greatly in importance to patients and when differences in apparent effect between components are large. We present an overview of CEPs with a focus on appropriate design and interpretation of results.
SN  - 0021-9355
M3  - doi: 10.2106/JBJS.K.01287
UR  - http://dx.doi.org/10.2106/JBJS.K.01287
ER  -