TY  - JOUR
T1  - Complications After Total Knee ArthroplastyHow to Manage Patients with Osteolysis
AU  - Scuderi, Giles R.
Y1  - 2011/11/16
N1  - 10.2106/JBJS.9322icl
JO  - The Journal of Bone & Joint Surgery
SP  - 2127
EP  - 2135
VL  - 93
IS  - 22
N2  - 
Total knee arthroplasty is one of the most successful orthopaedic procedures. It improves quality of life and has high patient satisfaction and excellent longevity, with survivorship of >90% at fifteen to twenty years. However, mechanical failure remains a complication. Debris particles, especially from polyethylene, affect the long-term durability of the implants1-3. Polyethylene debris incites a chemical and cellular inflammatory reaction, resulting in bone resorption and osteolysis. The extent of the osteolysis is dependent on the volume, size, and shape of the polyethylene debris. The main causative factor leading to osteolysis is small particulate debris, which stimulates an inflammatory foreign-body cellular response, resulting in bone resorption4. In contrast, the large polyethylene particles associated with delamination of the polyethylene and fatigue wear do not elicit the same cellular response2,3.

SN  - 0021-9355
M3  - doi: 10.2106/JBJS.9322icl
UR  - http://dx.doi.org/10.2106/JBJS.9322icl
ER  -