TY  - JOUR
T1  - Correspondence
AU  - Moran, Christopher G.
AU  - Chapman, Michael W.
AU  - Bucholz, Robert
AU  - Cornell, Charles
Y1  - 1998/03/01
N1  - 
JO  - The Journal of Bone & Joint Surgery
SP  - 454
EP  - 454
VL  - 80
IS  - 3
N2  - 
    I enjoyed the article "Treatment of Acute Fractures with a Collagen-Calcium Phosphate Graft Material. A Randomized Clinical Trial" (79-A: 495—502, April 1997), by Chapman et al. I was interested to note that the collagen component of the graft material was purified bovine dermal collagen. There are concerns that bovine spongiform encephalopathy, or mad-cow disease (a prion disease closely related to Creutzfeldt-Jakob syndrome), may be transmitted from cattle to humans. Prion protein is extremely difficult to destroy, and I am interested to know what steps are taken during the production of the collagen graft to ensure that these proteins are not present within the graft material.

SN  - 0021-9355
M3  - doi: 
UR  - http://dx.doi.org/
ER  -