TY  - JOUR
T1  - Correspondence
AU  - Hunt, D. M.
AU  - Holmes, Z.
AU  - Pickering, W.
AU  - Cohen, H.
AU  - Glueck, C. J.
AU  - Freiberg, Richard
AU  - Crawford, Alvin
AU  - Roy, Dennis
AU  - Glueck, Helen
AU  - Stroop, Davis
Y1  - 1998/04/01
N1  - 
JO  - The Journal of Bone & Joint Surgery
SP  - 604
EP  - b
VL  - 80
IS  - 4
N2  - 
    The etiology of Legg-Perthes disease is poorly understood, but recent reports have suggested a strong association with heritable thrombophilic defects. Glueck et al., in their study "Association of Antithrombotic Factor Deficiencies and Hypofibrinolysis with Legg-Perthes Disease" (78-A: 3—13, Jan. 1996), reported that 59 per cent (twenty-six) of forty-four children who had Legg-Perthes disease had a thrombophilic defect: nineteen (43 per cent) had protein-C deficiency, four (9 per cent) had protein-S deficiency, and three (7 per cent) had hypofibrinolysis. As part of an ongoing, unpublished study, we screened twelve white individuals who had Legg-Perthes disease for heritable thrombophilic defects. The ten male and two female patients had a median age of eleven years (range, six to forty-three years). None of the individuals had a personal or family history of thromboembolism.

SN  - 0021-9355
M3  - doi: 
UR  - http://dx.doi.org/
ER  -