TY - JOUR T1 - Institutional Review Board Approval: Why It Matters AU - Parvizi, Javad AU - Tarity, T. David AU - Conner, Kyle AU - Smith, J. Bruce Y1 - 2007/02/01 N1 - 10.2106/JBJS.F.00362 JO - The Journal of Bone & Joint Surgery SP - 418 EP - 426 VL - 89 IS - 2 N2 - The modern institutional review boards originated in the 1970s. They exist to protect human subjects participating in research from potential harm.The Belmont Report provided the ethical principles (respect for persons, beneficence, and justice) that should be observed while conducting research on human subjects.Compliance with the ethical principles of the Belmont Report is a first step in successful submissions to an institutional review board.Regulations regarding conflict of interest represent an attempt to ensure that research is not biased by financial or other interest and to maintain public trust. SN - 0021-9355 M3 - doi: 10.2106/JBJS.F.00362 UR - http://dx.doi.org/10.2106/JBJS.F.00362 ER -