TY  - JOUR
T1  - In Vivo Efficacy of Antimicrobial-Coated Devices
AU  - Darouiche, Rabih O.
Y1  - 2008/08/01
N1  - 
JO  - The Journal of Bone & Joint Surgery
SP  - 1785
EP  - 1786
VL  - 90
IS  - 8
N2  - 
I appreciate the concern by Dr. Neogi and colleagues for the potential development of rifampin resistance among agents of tuberculosis in scenarios where systemic antituberculous medications are suboptimally used. However, this potential concern does not necessarily imply that rifampin resistance is likely to occur among mycobacterial or bacterial organisms, including staphylococci, in patients who receive devices coated with the optimal combination of rifampin and minocycline. In fact, several clinical studies have shown no evidence for the development of rifampin resistance among bacterial organisms, including staphylococci, in patients who receive rifampin-minocycline-coated vascular catheters1-3.

SN  - 0021-9355
M3  - doi: 
UR  - http://dx.doi.org/
ER  -