TY  - JOUR
T1  - Tibial Cartilage Hypertrophy Due to Matrix-Associated Autologous Chondrocyte Transplantation of the Medial Femoral CondyleA Case Report
AU  - Welsch, Goetz H.
AU  - Trattnig, Siegfried
AU  - Tichy, Brigitte
AU  - Mamisch, Tallal C.
AU  - Wondrasch, Barbara
AU  - Marlovits, Stefan
Y1  - 2009/08/01
N1  - 10.2106/JBJS.H.01180
JO  - The Journal of Bone & Joint Surgery
SP  - 1996
EP  - 2001
VL  - 91
IS  - 8
N2  - 
Osteochondral graft hypertrophy is commonly seen after autologous chondrocyte transplantation with use of a periosteal flap1,2. Reoperation may be performed because of a high grade of hypertrophy causing persistent clinical symptoms. The use of a collagen membrane to cover the chondrocyte suspension can reduce the risk of graft hypertrophy3,4. Further technological advances have led to a third generation of autologous chondrocyte transplantation with use of biomaterials seeded with chondrocytes as so-called all-in-one scaffolds that generate new articular cartilage5. Nevertheless, graft hypertrophy continues to occur, although the prevalence has been reduced with matrix-associated autologous chondrocyte transplantation6,7.

SN  - 0021-9355
M3  - doi: 10.2106/JBJS.H.01180
UR  - http://dx.doi.org/10.2106/JBJS.H.01180
ER  -