TY  - JOUR
T1  - Aneurysmal Bone Cysts of Soft Tissue Represent True NeoplasmsA Report of Two Cases
AU  - Pietschmann, Matthias F.
AU  - Oliveira, Andre M.
AU  - Chou, Margaret M.
AU  - Ihrler, Stefan
AU  - Niederhagen, Manuel
AU  - Baur-Melnyk, Andrea
AU  - Dürr, Hans Roland
Y1  - 2011/05/04
N1  - 10.2106/JBJS.J.00534
JO  - The Journal of Bone & Joint Surgery
SP  - e45 1
EP  - 8
VL  - 93
IS  - 9
N2  - 
Aneurysmal bone cyst was first described by Jaffe and Lichtenstein in 19421. It is considered a benign, locally aggressive lesion with a potential for local recurrence, and it typically appears in the metaphysis of the long bones and in the vertebral column2-4. Mostly, children and young adults are affected. No sex predilection has been observed. Radiographically, aneurysmal bone cyst is seen as a lytic lesion, usually eccentrically located and expansile but with well-defined margins. Histologically, there are blood-filled cysts separated by fibrous septa, with fibroblasts as well as osteoclast-type giant cells and reactive woven bone5. Historically, aneurysmal bone cyst was believed to occur exclusively in bone6. In 1972, Salm and Sissons noted soft-tissue lesions resembling aneurysmal bone cysts, and this was probably the first description of this entity7. For many years, aneurysmal bone cyst was thought to be a lesion, reactive in nature, caused by a circulatory abnormality leading to an increased venous pressure and resulting in dilation of the vascular network2,8,9. In recent years, strong evidence has supported the neoplastic nature of aneurysmal bone cyst10-13. In 1999, Panoutsakopoulos et al.10 demonstrated chromosomal translocation t(16;17)(q22;p13) as a recurrent cytogenetic abnormality in primary aneurysmal bone cyst, which was confirmed by other groups11-13. We report two cases of soft-tissue aneurysmal bone cyst with USP6 locus rearrangement on chromosome 17p13. The patients were informed that data concerning their cases would be submitted for publication, and they consented.

SN  - 0021-9355
M3  - doi: 10.2106/JBJS.J.00534
UR  - http://dx.doi.org/10.2106/JBJS.J.00534
ER  -