TY  - JOUR
T1  - Cobalt and Chromium Levels in Blood and Urine Following Hip Resurfacing Arthroplasty with the Conserve Plus Implant
AU  - Kim, Paul R.
AU  - Beaulé, Paul E.
AU  - Dunbar, Michael
AU  - Lee, Joshua K.L.
AU  - Birkett, Nicholas
AU  - Turner, Michelle C.
AU  - Yenugadhati, Nagarajkumar
AU  - Armstrong, Vic
AU  - Krewski, Daniel
Y1  - 2011/05/04
N1  - 10.2106/JBJS.J.01721
JO  - The Journal of Bone & Joint Surgery
SP  - 107
EP  - 117
VL  - 93
IS  - Supplement_2
N2  - Background: 
  The purpose of the present study was to determine cobalt and chromium ion levels in the blood and urine of patients in whom a modern-generation metal-on-metal hip resurfacing device had been implanted.Methods: 
  A total of ninety-seven patients with a Conserve Plus metal-on-metal hip resurfacing implant were followed prospectively for two years. Cobalt and chromium levels in erythrocytes, serum, and urine were measured preoperatively as well as three, six, twelve, and twenty-four months postoperatively.Results: 
  The median serum cobalt and chromium ion levels were 1.04 µg/L (range, 0.31 to 7.42 µg/L) and 2.00 µg/L (range, 0.28 to 10.49 µg/L), respectively, at one year after surgery and 1.08 µg/L (range, 0.44 to 7.13 µg/L) and 1.64 µg/L (range, 0.47 to 10.95 µg/L), respectively, at two years after surgery. The corresponding mean levels (and standard deviations) of serum cobalt and chromium were 1.68 ± 1.66 µg/L and 2.70 ± 2.22 µg/L, respectively, at one year after surgery and 1.79 ± 1.66 µg/L and 2.70 ± 2.37 µg/L, respectively, at two years after surgery.Conclusions: 
  These levels compare favorably with other published ion results for metal-on-metal hip resurfacing and replacement implants. No pseudotumors or other adverse soft-tissue reactions were encountered in our study population. Further research is needed to determine the clinical importance of increased cobalt and chromium ion levels in serum and urine following metal-on-metal hip resurfacing.Level of Evidence: 
  Therapeutic Level IV. See Instructions to Authors for a complete description of levels of evidence.
SN  - 0021-9355
M3  - doi: 10.2106/JBJS.J.01721
UR  - http://dx.doi.org/10.2106/JBJS.J.01721
ER  -