TY - JOUR T1 - Ipsilateral Graft and Contralateral ACL Rupture at Five Years or More Following ACL ReconstructionA Systematic Review AU - Wright, Rick W. AU - Magnussen, Robert A. AU - Dunn, Warren R. AU - Spindler, Kurt P. Y1 - 2011/06/15 N1 - 10.2106/JBJS.J.00898 JO - The Journal of Bone & Joint Surgery SP - 1159 EP - 1165 VL - 93 IS - 12 N2 - Background:  Injury to the ipsilateral graft used for reconstruction of the anterior cruciate ligament (ACL) or a new injury to the contralateral ACL is a devastating outcome following successful ACL reconstruction, rehabilitation, and return to sport. Little evidence exists regarding the intermediate to long-term risk of these events.Methods:  The present study is a systematic review of Level-I and II prospective studies that evaluated the rate of rupture of the ACL graft and the ACL in the contralateral knee following a primary ACL reconstruction with use of a mini-open or arthroscopic bone-tendon-bone or hamstring autograft after a minimum duration of follow-up of five years.Results:  Six studies met the inclusion and exclusion criteria. The ipsilateral ACL graft rupture rate ranged from 1.8% to 10.4%, with a pooled percentage of 5.8%. The contralateral injury rate ranged from 8.2% to 16.0%, with a pooled percentage of 11.8%.Conclusions:  This systematic review demonstrates that the risk of ACL tear in the contralateral knee (11.8%) is double the risk of ACL graft rupture in the ipsilateral knee (5.8%). Additional studies must be performed to determine predictors for these injuries and to improve our ability to avoid this devastating outcome.Level of Evidence:  Prognostic Level II. See Instructions to Authors for a complete description of levels of evidence. SN - 0021-9355 M3 - doi: 10.2106/JBJS.J.00898 UR - http://dx.doi.org/10.2106/JBJS.J.00898 ER -