TY  - JOUR
T1  - Arthroprosthetic Cobaltism: Neurological and Cardiac Manifestations in Two Patients with Metal-on-Metal ArthroplastyA Case Report
AU  - Tower, Stephen S.
Y1  - 2010/12/01
N1  - 10.2106/JBJS.J.00125
JO  - The Journal of Bone & Joint Surgery
SP  - 2847
EP  - 2851
VL  - 92
IS  - 17
N2  - 
Early failure of metal-on-metal hip arthroplasties is a current concern because tissue damage resulting from periprosthetic metallosis can compromise subsequent revision arthroplasty1,2. The United Kingdom's Medicines and Healthcare products Regulatory Agency has advised that patients with metal-on-metal implants who have pain, prosthetic malposition, or implants that are known to have excessive failure rates should be evaluated with the measurement of serum cobalt. A serum cobalt level of >7 µg/L indicates possible periprosthetic metallosis3,4. A normal serum cobalt level is 0.19 µg/L, and 95% of those who are unexposed to cobalt have a value of <0.41 µg/L5. A serum cobalt level of >1 µg/L indicates excessive cobalt exposure, and levels of >5 µg/L are considered toxic6.

SN  - 0021-9355
M3  - doi: 10.2106/JBJS.J.00125
UR  - http://dx.doi.org/10.2106/JBJS.J.00125
ER  -