Response/Recommendation: There is currently no evidence in the literature to determine if a diabetic patient undergoing ulcer debridement requires venous thromboembolism (VTE) prophylaxis. There is, however, an increased risk for morbidity and mortality in diabetic foot ulcers (DFU) patients who develop VTE. Therefore, it is justified to propose that patients with DFU are given thromboprophylaxis, particularly if they have reduced mobility and other medical comorbidities. This may not be true for all cases of surgical debridement alone of DFU without additional interventions when prolonged limited weight-bearing is not required.