Genicular artery embolization (GAE) is a promising treatment option for patients with knee osteoarthritis who are unresponsive to nonsurgical treatments and not yet candidates for surgery.

Current evidence supports the effectiveness of GAE in reducing pain and synovitis, with few reported major adverse events.

The cost-effectiveness and long-term results of GAE compared with other treatment options require further investigation.

Limitations of existing studies include small sample sizes, single-center trials, and lack of comparison between embolic agents and other treatments.

Future research should focus on larger, multicenter trials with longer follow-up periods and head-to-head comparisons with alternative treatment modalities to establish the role of GAE in the management of knee osteoarthritis.